To get more detailed information please visit, a website that was created and funded by the John Grube Foundation e.V.

Granulomatosis with Polyangiitis (Morbus Wegener)

Currently, there is not much information about GPA widely available on the internet. For this reason, the John Grube Foundation e.V. is working to improve access to information. At this point of time, we are working on a website which will be managed by doctors. This will enable those affected with GPA, along those looking for more information to receive the most accurate information, and not be sidetracked with misinformation. Until the website is fully operational, we have a brief overview of the disease on our site, as well as, links to sources that - in our opinion - are reliable. 


Granulomatosis with polyangiitis (GPA), also known as Wegener’s disease, is an autoimmune disease. The systemic disease of the vascular system leads to inflammation of blood vessels. This leads to a deficient blood supply to the affected organs. In general, any tissue can be affected. Typical organs which are affected by GPA and therefore are building granulomas (inflammations) are the lungs, kidneys, eyes, ears, nose, and the throat areas. The causes of the occurrence of this autoimmune disease are unknown so far. 

The disease belongs to the so-called ANCA-associated small vessel vasculitis and is rare: Every year 5-12 people per one million inhabitants are affected by GPA. The disease usually occurs between the ages of 40 and 50; women and men are equally affected.

Useful sources of information